Schedule-Induced Polydipsia: Searching for the Endophenotype of Compulsive Behavior

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The motivational properties of schedule-induced polydipsia.

Schedule-induced polydipsia occurred during initial magazine training to Noyes pellets (45 mg), disappeared when lever-pressing was acquired on a continuous reinforcement schedule (CRF), and reappeared when the food contingency was changed to a 1-min variable interval schedule (VI 1 min). Polydipsia also developed under a VI 1 min food schedule when water was concurrently available on various f...

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Impaired GABA Plasticity at ovBNST Synapses Predicts Compulsive Drinking in Schedule-Induced Polydipsia. By

........................................................................................................i Co-Authorship.................................................................................................ii Acknowledgements...........................................................................................iii List of Figures.......................................................

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Schedule-induced polydipsia as a function of fixed interval length.

Rats were trained to bar-press for Noyes pellets on an FI schedule which was increased serially through several values from 2 sec to as high as 300 sec. Concurrently, water was freely available. As FI length was increased, the degree of polydipsia increased linearly to a maximum value.

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Taste aversion learning and schedule-induced polydipsia in rats

Experiment 1 sought to determine whether schedule-induced drinking could be abolished by means of a taste aversion. Polydipsic rats were given access to a .4% saccharin solution while they were exposed to an intermittent food schedule. Immediately after the session, they received an intraperitoneal injection of either lithium chloride or sodium chloride. Following a recovery day with water in t...

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Unilateral substantia nigra lesions and schedule-induced polydipsia.

The present experiment investigated the effects of unilateral 6-hydroxydopamine lesions of the substantia nigra (SN) on schedule-induced polydipsia (SIP). Lesions were made in either the "dominant" or "non-dominant" hemisphere as defined by an amphetamine rotation test. It was found that unilateral lesions of either the "dominant" or "non-dominant" SN significantly reduced SIP and also signific...

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ژورنال

عنوان ژورنال: World Journal of Neuroscience

سال: 2014

ISSN: 2162-2000,2162-2019

DOI: 10.4236/wjns.2014.43029